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Hypothalamic paraventricular nucleus (PVN) is a major source of arginine vasopressin (AVP). Our previous work has proven that: (1) pain stimulation enhances PVN synthesis and secretion of AVP; (2) AVP in periaqueductal gray (PAG) plays a role in antinociception; (3) pain stimulation increases AVP concentration in PAG tissue. The present study was to investigate AVP source in PAG during pain modulation...
Previous study has proven that arginine vasopressin (AVP) enhances periaqueductal gray (PAG) secreting enkephalin and endorphin in vivo in the rat. Present work investigated that AVP effect on PAG secretion and synthesis of enkephalin and endorphin in vitro. Radioimmunoassy results showed that AVP increased leucine-enkephalin (L-Ek), methionine-enkephalin (M-Ek), β-endorphin (β-Ep) rather than dynorphin...
The effect of arginine vasopressin (AVP) on rat antinociception was investigated. Intraventricular injection of 50 or 100ng AVP dose-dependently increased the pain threshold; in contrast, intraventricular injection of 10μl anti-AVP serum decreased the pain threshold; both intrathecal injection of 200ng AVP or 10μl anti-AVP serum and intravenous injection of 5μg AVP or 200μl anti-AVP serum did not...
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