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This paper demonstrates that polarization microscopy can be a very useful tool for observing the dissolution processes of electrospun drug-loaded nanofiber mats, and thus providing useful information for preparing drug-loaded nanofibers with high quality. With icariin as the model active pharmaceutical ingredient and PVP K30 and K60 as filament-forming matrix, three different types of drug-loaded...
The triple-shelled hollow spheres with optical properties were prepared via reversible addition-fragmentation chain transfer (RAFT) polymerization. After removal the core templates of the poly (styrene), the hollow silica spheres were obtained. The coating process of poly (methyl methacrylate) (PMMA) on the hollow silica spheres surface via surface RAFT polymerization was performed subsequently. The...
Fast dissolution nanofiber membranes were prepared using electrospinning process with Ferulic Acid (FA)--a traditional Chinese medicine as the active pharmaceutical ingredients and a pharmaceutical hydrophilic polymer--polyvinylpyrrolidone K30 as the filament-forming matrix. Field Emission Scanning Electronic Microscopy (FE-SEM), Differential Scanning Calorimetry (DSC), Attenuated Total Reflection...
A kind of polymeric prodrug of ibuprofen with glucose pendant was prepared through chemo-enzymatic method. The obtained polymeric prodrug was characterized by FT-IR, NMR and GPC. The molecular weight of the polymeric prodrug reached 2.126 × 104. Furthermore, the in vitro release behaviors of ibuprofen (raw drug) and the polymeric prodrug were investigated in pH 7.4 buffer solution at 37°C. It was...
Biodegradable polymer polycaprolactone (PCL; Mw~100,000) fiber mats containing shikonin from the plant Lithospermumerythrorhizon, widely known for its wound healing, anti-tumor, antioxidant, and anti-inflammatory properties, were prepared via electrospinning method. Incorporation of shikonin in the neat PCL solution did not affect the morphology of the resulting fibers, as both the neat and the shikonin-loaded...
Novel membranes were prepared through covalently coupling of chitosan (CS) to activate nylon membrane after the reaction of the microporous nylon membrane with formaldehyde. Non-specific adsorption on the CS-coated nylon membrane decreased greatly. Yellow 3G-P/Reactive Red 120 were then covalently immobilized onto composite membrane as dye ligands. These Red 120/Yellow 3G-P-CS-membranes were used...
A novel drug delivery device (DDD) with complex structures for providing linear drug release profiles was designed and fabricated directly from the CAD models using three-dimensional printing technique (3DP) systems. The DDDs were in donut shape and had local concentration variations of the release-retarding polymer in their three regions. Environmental scanning electron microscopy clearly showed...
A facile procedure combining enzymatic resolution with chemical polymerization was developed to prepare optically active polymeric prodrug containing glucose. Polymerizable optically active (R)-1-O-vinyladipoyl-chlorphenesin ((R)-OVAC) was obtained in excellent optically purity (ee>99.9%) and high yield (~50%) in short time, and optically active (S)-N-vinyladipoyl-propranolol ((S)-NVAP) was obtained...
Electrospun nylon-6 nanofibrous membrane with fiber diameters in the range of 50-200 nm were prepared and employed as affinity membrane material for papain adsorption due to their excellent chemical and thermal resistance as well as high wettability. In this work, covalent coupling of chitosan (CS) to activated nylon membrane was performed after the reaction of the nanofibrous nylon membrane with...
The present study provides the methods of preparing organic/inorganic hybrid nanofiber mats. A simple process was developed in preparing polyacrylonitrile/kaolinite hybrid nanofiber mats based on electrospinning technology. The electrospinning of sub-nano kaolinite particles-contained PAN suspensions resulted in uniform distribution of kaolinite particles among the PAN nanofibers, which was demonstrated...
Nylon membranes are first hydrolyed with dilute HCl and then treated with chitosan before being used as the affinity carrier. Papain as a ligand has been immobilized on the activated membranes with glutaraldehyde as a crosslinking agent. The factors involving with the activity of immobilized papain, such as concentration of glutaraldehyde, pH, temperature, reaction time, and the amount of added papain...
In the present study, Eudragit L100 was successfully spun into ultrafine fibers using electrospinning process. The electrospinnability of Eudragit L100 in DMAc, ethanol, methanol, and the mixed solvents of DMAc and methanol with different ratios were examined. The morphologies of the as-spun Eudragit L100 fiber mats were observed using SEM. The results demonstrated that Eudragit L100 was able to be...
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