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The blood–brain barrier (BBB) keeps the central nervous system (CNS) safe from various brain diseases, while the BBB makes it difficult for effective drugs to enter the CNS. Mfsd2a is specifically expressed on the cell membrane of brain-microvascular endothelial cell (BMEC) and is implicated in the delivery of some substances across the BBB. Mfsd2a is the first inhibitor of the transcytosis and the...
Nuclear-targeted therapy by delivering anticancer drug directly into cancer cell nuclei can elicit synergistic therapeutic effects and kill these cancer cells with much enhanced efficiencies. Besides nuclear targeting, another difficulty in nuclear-targeted therapy is how to achieve real-time monitoring of the therapy process simultaneously. In this article we report on the development of multifunctional...
This paper demonstrates that polarization microscopy can be a very useful tool for observing the dissolution processes of electrospun drug-loaded nanofiber mats, and thus providing useful information for preparing drug-loaded nanofibers with high quality. With icariin as the model active pharmaceutical ingredient and PVP K30 and K60 as filament-forming matrix, three different types of drug-loaded...
Fast dissolution nanofiber membranes were prepared using electrospinning process with Ferulic Acid (FA)--a traditional Chinese medicine as the active pharmaceutical ingredients and a pharmaceutical hydrophilic polymer--polyvinylpyrrolidone K30 as the filament-forming matrix. Field Emission Scanning Electronic Microscopy (FE-SEM), Differential Scanning Calorimetry (DSC), Attenuated Total Reflection...
Sustained-release floating drug delivery systems (FDDSs) enable prolonged and continuous input of the drug to the upper parts of the gastrointestinal tract have been designed and fabricated using three dimensional printing (3DP) technology. A new strategy is proposed for the development of FDDSs. The design of FDDSs was based on the sustained release formulation, with low density and floating features...
In the present study, Eudragit L100 was successfully spun into ultrafine fibers using electrospinning process. The electrospinnability of Eudragit L100 in DMAc, ethanol, methanol, and the mixed solvents of DMAc and methanol with different ratios were examined. The morphologies of the as-spun Eudragit L100 fiber mats were observed using SEM. The results demonstrated that Eudragit L100 was able to be...
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