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Front Cover. From the deep‐sea gammarid shrimp‐derived Penicillium citrinum XIA‐16, one new and 25 known compounds were obtained. Penicitrinol B significantly inhibited RSL3‐induced ferroptosis by reducing lipid peroxidation and heme oxygenase 1 (HMOX1) expression; while penicitrinol A was able to inhibit cuproptosis, implying their potential as drug leads against aging, neurodegenerative diseases,...
One new alkaloid, (S)‐2‐acetamido‐4‐(2‐(methylamino)phenyl)‐4‐oxobutanoic acid (1), was isolated from the deep‐sea‐derived Penicillium citrinum XIA‐16, together with 25 known compounds including ten polyketones (2–11), eight alkaloids (12–19), six steroids (20–25), and a fatty acid (26). Their planar and relative structures were determined by an analysis of 1D and 2D nuclear magnetic resonance (NMR)...
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