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Previous studies have shown that cytosolic Ca 2+ ([Ca 2+ ] c ) overload was involved in Pb-induced apoptosis in primary cultures of rat proximal tubular (rPT) cells, but the source of elevated Ca 2+ and the effect of potential subcellular Ca 2+ redistribution on apoptosis are still unknown. In this study, variations of [Ca 2+ ] c in two culture...
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