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Genistein (GEN) is one of the major soy isoflavones. It is particularly effective in quenching free radicals generated by toxic agents. On account of its anti-oxidant property, it may protect cancer cells from free radical damage in photodynamic (PDT) during which reactive oxygen species (ROS) production was stimulated leading to irreversible tumor cell injury. In this study, the influence of genistein...
The DNA damage and subcellular of copper (Cu) in 8-day-exposure winter wheat (Triticum aestivum L.) were studied to determine Cu genotoxicity mechanisms and compartmentalization. The results showed Cu induced DNA damage significantly in all treated plants, roots are more cytotoxic and genotoxic than shoots. The translocation factors (ratio of Cu concentrations in shoots to those in roots) were from...
To explore the chronic hematologic toxicity in BALB/C mice exposed to low concentration of benzene which is equal to concentration of Chinese occupational hygiene standard, the benzene (20mg/m3) was applied to BALB/C mice by inhalation exposure, once per day, for 3 month and the mice were raised for another 90 days after exposure. During the experimental period, micronucleus frequency in peripheral...
To study mechanism of resveratrol induce tumor cell apoptosis through mitochondria pathways. Measurements using mononuclear cell direct cytotoxicity assay shows that its cytotoxic effect on HepG-2 is strong with IC50 being 34.86 mumolldrL-1. Measurement of action of apoptosis using morphology with Hoechst 33258 stain show that karyoplasmic ratio of tumor cells diminish, cell nucleus pyconsis, the...
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