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The cyclin-dependent kinases (Cdks) are a family of serine/threonine protein kinases whose members are small proteins (~34-40 kDa) composed of little more than the catalytic core shared by all protein kinases. All Cdks share the feature that their enzymatic activation requires the binding of a regulatory cyclin subunit. Various combination of both cyclin dependent kinases (CDKs) and cyclin proteins...
The MMPs and ADAMs are cell surface proteases which belong to metalloprotease family. They play an important role in skin aging, skin disorders, anticancer therapy and other physiological disorders. Thus there arises the need to understand the relationships among various parameters of these proteins for prediction of their classes, structures and functionality. The computational approaches for prediction...
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