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The central nervous system is composed of many different interacting neurons all working together to provide sensory, motor, and visceral signals to the specific organism. The environment in which those neurons operate is crucial to the survival of the organism. Some environmental factors may include pH, temperature, or the intra-and extracellular ion concentration. If any of these factors are changed...
Dimethylformamide (DMF) is a hydrophilic aprotic solvent often used in peptide coupling, an essential process in the pharmaceutical industry. Its use in biological study is typically in the role of a peptide solvent when evaluating the efficacy of peptides and their effect on the cellular membrane. In evaluating the effect of the peptide gramicidin on neurons of the central nervous system (CNS) of...
Gramicidin is a pore-forming peptide which exhibits lethal properties against a large spectrum of cells. It forms monovalent cation-specific channel in the lipid bilayer of a cellular membrane with limited permeability to anions or polyvalent cations. Both ions and water move through the pore which is formed by the peptide backbone. We detected formation of pores induced by the dimerization of gramicidin...
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