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The authors describe a colorimetric assay for the determination of the iron chelating drug deferiprone by using water dispersible silver nanoparticles functionalized with pyrophosphate groups (Pyro-AgNPs). The pyro-AgNPs are capable of cooperatively binding Fe3+ ions, and this results in a color change from yellow (peaking at 402 nm) to red (peaking at 520 nm) due to aggregation. However, this binding...
A simple, accurate and precise high-performance thin-layer chromatographic method has been developed and validated for the analysis of proton pump inhibitors (PPIs) and their co-formulated drugs, available as binary combination. Planar chromatographic separation was achieved using a single mobile phase comprising of toluene: iso-propranol: acetone: ammonia 5.0:2.3:2.5:0.2 (v/v/v/v) for the analysis...
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