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The α2C‐adrenoceptor (α2C‐AR) is regarded as one of the potential targets for antipsychotics. A few of structurally diverse α2C‐AR antagonists have been reported, among which ORM‐10921, containing one rigid tetracyclic framework with two neighboring chiral centers, has exhibited remarkable antipsychotic‐like effects and pro‐cognitive properties in different animal models. Yet the binding mode of ORM‐10921...