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Chronic treatment with cyclosporine A (CyA) is often complicated by severe hypertension. If activation of the β-adrenergic-receptor-linked adenylyl cyclase (AC) system contributes to hypertension is unresolved. Rats were treated with CyA (20 mg kg−1 day−1) for 7 days. β-adrenergic, muscarinic, and α-adrenergic receptors, G-proteins, and the activity of AC were determined in cardiac and pulmonary plasma...
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