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Carmustine [1,3-bis(2-chloroethyl)-1-nitrosurea (BCNU)] is an antitumour agent, however, its usefulness has been limited by a side effect; which involves pericholangitis and intrahepatic cholestasis. The primary effects of cholestasis is well known; bile flow retention, intracellular Ca ++ accumulation and acidosis although it may lead to hepatotoxicity by dose-dependent manner. Recent studies...
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