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The serrated pathway (SP) can be viewed as two parallel, but partially overlapping, arrays of colorectal precursor lesions, and their respective endpoint carcinomas, that are distinct from those of the conventional adenoma–carcinoma sequence (APC‐pathway). In this review we focus at the outset on the clinical impact, pathological features, molecular genetics and biological behaviours of the various...
The serrated polyp pathway comprises a morphologically distinct group of colorectal neoplasms and represents an alternative molecular pathway to colorectal cancer. The earliest lesion is a non-dysplastic serrated polyp (hyperplastic polyp) or precursor serrated aberrant crypt focus with an activating mutation of the BRAF oncogene; this may progress via an atypical hyperplastic polyp variant (sessile...
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