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Bioluminescence imaging (BLI) offers an alternative opportunity for non-invasively visualizing biological processes at the physiological and molecular levels in whole animals. Tomographic bioluminescence imaging (TBI) can further translate planar imaging into three-dimensional quantitative bioluminescent source distribution. Although many reconstruction methods have been developed, efforts are still...
Bioluminescence imaging (BLI) and bioluminescence tomography (BLT) make it possible to elucidate cellular signatures to better understand the effects of human disease in small animal in vivo. However, to the best of our knowledge, the existing gradient-type reconstruction methods in BLT are not very efficient, and often require a relatively small volume of interest (VOI) for feasible results. In this...
Tomographic bioluminescence imaging suffers from poor imaging robustness, since it is severely affected by selection of regularization parameter (RP) and initialization for source distribution. In this paper, a global-inexact-Newton based reconstruction methodology, which is regularized by a dynamic sparse term, is demonstrated for in vivo tomographic imaging. The novel method can enhance higher imaging...
Fluorescence molecular tomography has become a promising technique for in vivo small animal imaging and has many potential applications. Due to the ill-posed and the ill-conditioned nature of the problem, Tikhonov regularization is generally adopted to stabilize the solution. However, the result is usually over-smoothed. In this letter, the third-order simplified spherical harmonics approximation...
As a novel optical molecular imaging technology, bioluminescence tomography (BLT) has become a research focus which can localize and quantify an internal light source with the bioluminescent signal on the external surface of a small animal. However, BLT is ill-posed because of complex photon propagation in the biological tissue and noisy boundary measured data. Moreover, the disadvantage of the finite...
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