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Objectives To clarify the metabolism of ara-C to uracil arabinoside (ara-U, inactive form) and ara-CTP (active form) in vivo in patients with hematologic malignancies.Design & Methods ara-C was administered as iv inf for intermediate dose (1.0 g/m 2 ) and as sc bolus or continuous iv for low-dose therapy (3 10 mg/m 2 ). ara-C and ara-U levels were determined by HPLC or RIA...
According to the four component theory, urate transport in nephrons consists of 4 steps, glomerular filtration (GF), presecretory reabsorption, secretion and postsecretary reabsorption. We have been investigating quantitatively the relationship among the steps of urate transport and urinary urate excretion (Uua) using the formulaUua = {Ccr (1 - R 1 ) + Cs} Sua (1 - R 2 )where...
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