Search results for: K. Hedman

Items from 1 to 20 out of 41 results

article

Liraglutide effects in a paediatric (7‐11 y) population with obesity: A randomized, double‐blind, placebo‐controlled, short‐term trial to assess safety, tolerability, pharmacokinetics, and pharmacodynamics

Lucy D. Mastrandrea, Louise Witten, Kristin C. Carlsson Petri, Paula M. Hale, more

Background Childhood obesity is a major public health concern with limited treatment options. Objective The aim of this study was to assess safety, tolerability, pharmacokinetics, and pharmacodynamics during short‐term treatment with liraglutide in children (7‐11 y) with obesity. Methods In this randomized, double‐blind, placebo‐controlled trial, 24 children received at least one dose of once‐daily...

article

Vascular characteristics in young women—Effect of extensive endurance training or a sedentary lifestyle

N. Bjarnegård, T. Länne, M. Cinthio, J. Ekstrand, more

Acta Physiologica > 223 > 2 > n/a - n/a

Aim To explore whether high‐level endurance training in early age has an influence on the arterial wall properties in young women. Methods Forty‐seven athletes (ATH) and 52 controls (CTR), all 17‐25 years of age, were further divided into runners (RUN), whole‐body endurance athletes (WBA), sedentary controls (SC) and normally active controls (AC). Two‐dimensional ultrasound scanning of the carotid...

article

Respiratory motion reduction with a dual gating approach in myocardial perfusion SPECT: Effect on left ventricular functional parameters

Matti J. Kortelainen, Tuomas M. Koivumäki, Marko J. Vauhkonen, Marja K. Hedman, more

Journal of Nuclear Cardiology > 2018 > 25 > 5 > 1633-1641

Background Respiratory motion (RM) complicates the analysis of myocardial perfusion (MP) single-photon emission computed tomography (SPECT) images. The effects of RM on left ventricular (LV) functional variables have not been thoroughly investigated. Methods and results Thoracic electrical bioimpedance and electrocardiographic signals were recorded from eighteen patients undergoing the rest phase...

article

DNA methylation patterns associated with oxidative stress in an ageing population

Åsa K. Hedman, Mihkel Zilmer, Johan Sundström, Lars Lind, more

BMC Medical Genomics > 2016 > 9 > 1 > 1-12

Background Oxidative stress has been related to type 2 diabetes (T2D) and cardiovascular disease (CVD), the leading global cause of death. Contributions of environmental factors such as oxidative stress on complex traits and disease may be partly mediated through changes in epigenetic marks (e.g. DNA methylation). Studies relating differential methylation with intermediate phenotypes and disease endpoints...

chapter

Replication of and Protein Synthesis by TT Viruses

L. Kakkola, K. Hedman, J. Qiu, D. Pintel, more

Current Topics in Microbiology and Immunology > TT Viruses > 53-64

The host cells and the events in the cells during Torque teno (TT) virus infection are at present unknown. Replicating TT virus DNA has been detected in liver, in peripheral blood mononuclear cells (PBMC), and in bone marrow. By alternative splicing this small virus generates three mRNA species, from which by alternative translation initiation at least six proteins are produced. The functions of the...

article

Detection and monitoring of human bocavirus 1 infection by a new rapid antigen test

A.H.L. Bruning, P. Susi, H. Toivola, A. Christensen, more

New Microbes and New Infections > 2016 > 11 > Complete > 17-19

Clinically relevant diagnosis of human bocavirus 1 (HBoV1) is challenging, as the virus is frequently detected in asymptomatic patients, and cofindings with other respiratory viruses are common. The clinical value of current diagnostic methods, such as PCR, is therefore low, and alternative diagnostic strategies are needed. We describe for the first time the use of an antigen detection assay for the...

article

The chemokine CXCL-10 and viral DNA levels correlate with different stages of Parvovirus B19 infection

L. Weseslindtner, L. Hedman, K. Hedman, J.H. Aberle

Journal of Clinical Virology > 2015 > 70 > Supplement 1 > S12

article

Torque teno virus primary infection in children

E. Väisänen, I. Kuisma, V. Simell, M. Mäkinen, more

Journal of Clinical Virology > 2015 > 70 > Supplement 1 > S10

article

Microsphere-based IgG avidity assays using as model human parvovirus B19 and CMV

Yilin Wang, L. Hedman, V. Nurmi, I. Ziemele, more

Journal of Clinical Virology > 2015 > 70 > Supplement 1 > S104

article

Bones hold the key to virus history and epidemiology

M. Toppinen, M.F. Perdomo, J. Palo, P. Simmonds, more

Journal of Clinical Virology > 2015 > 70 > Supplement 1 > S81

article

Multiplex detection of all currently known human polyomaviruses

R. Sadeghi, T. Ramqvist, Yilin Wang, M. Söderlund-Venermo, more

Journal of Clinical Virology > 2015 > 70 > Supplement 1 > S121

article

A new quantitative PCR for human parvovirus B19 genotypes

M. Toppinen, P. Norja, L.-M. Aaltonen, S. Wessberg, more

Journal of Virological Methods > 2015 > 218 > Complete > 40-45

Parvovirus B19 (B19V) is a minute ssDNA virus associated with a wide range of diseases from childhood erythema to fetal death. After primary infection, the viral genomes persist lifelong in solid tissues of most types. Quantification of the viral DNA is important in the timing of primary infection, assessment of tissue persistence and screening of blood donor plasma. In this study, we present a new...

article

Female athlete's heart: Systolic and diastolic function related to circulatory dimensions

K. Hedman, É. Tamás, J. Henriksson, N. Bjarnegård, more

Scandinavian Journal of Medicine & Science in Sports > 25 > 3 > 372 - 381

There are relatively few studies on female athletes examining cardiac size and function and how these measures relate to maximal oxygen uptake (VO_2max). When determining sports eligibility, it is important to know what physiological adaptations and characteristics may be expected in female athletes, taking body and cardiac size into account. The purposes of this study were (a) to compare right and...

article

A two-step real-time PCR assay for quantitation and genotyping of human parvovirus 4

E. Väisänen, A. Lahtinen, A.M. Eis-Hübinger, M. Lappalainen, more

Journal of Virological Methods > 2014 > 195 > Complete > 106-111

Human parvovirus 4 (PARV4) of the family Parvoviridae was discovered in a plasma sample of a patient with an undiagnosed acute infection in 2005. Currently, three PARV4 genotypes have been identified, however, with an unknown clinical significance. Interestingly, these genotypes seem to differ in epidemiology. In Northern Europe, USA and Asia, genotypes 1 and 2 have been found to occur mainly in persons...

article

Global Analysis of DNA Methylation Variation in Adipose Tissue from Twins Reveals Links to Disease-Associated Variants in Distal Regulatory Elements

Kourosh R. Ahmadi, Chrysanthi Ainali, Amy Barrett, Veronique Bataille, more

The American Journal of Human Genetics > 2013 > 93 > 6 > 1158

article

Global Analysis of DNA Methylation Variation in Adipose Tissue from Twins Reveals Links to Disease-Associated Variants in Distal Regulatory Elements

Kourosh R. Ahmadi, Chrysanthi Ainali, Amy Barrett, Veronique Bataille, more

The American Journal of Human Genetics > 2013 > 93 > 5 > 876-890

article

Gene expression changes with age in skin, adipose tissue, blood and brain

Daniel Glass, Ana Viñuela, Matthew N Davies, Adaikalavan Ramasamy, more

Genome Biology > 2013 > 14 > 7 > 1-12

Background Previous studies have demonstrated that gene expression levels change with age. These changes are hypothesized to influence the aging rate of an individual. We analyzed gene expression changes with age in abdominal skin, subcutaneous adipose tissue and lymphoblastoid cell lines in 856 female twins in the age range of 39-85 years. Additionally, we investigated genotypic variants involved...

article

Platinum Interference with siRNA Non-seed Regions Fine-Tunes Silencing Capacity

Hanna K. Hedman, Finn Kirpekar, Sofi K. C. Elmroth

Journal of the American Chemical Society > 2011 > 133 > 31 > 11977 - 11984

article

Comparison of Th‐cell Immunity Against Human Bocavirus and Parvovirus B19: Proliferation and Cytokine Responses are Similar in Magnitude but More Closely Interrelated with Human Bocavirus

A. Kumar, C. Filippone, A. Lahtinen, L. Hedman, more

Scandinavian Journal of Immunology > 73 > 2 > 135 - 140

Human parvovirus B19 (B19) has been, for decades, the only parvovirus known to be pathogenic in humans. Another pathogenic human parvovirus, human bocavirus (HBoV), was recently identified in respiratory samples from children with acute lower respiratory tract symptoms. Both B19 and HBoV are transmitted by the respiratory route. The vast majority of adults are IgG seropositive for HBoV, whereas the...

article

Synthesis and DNA Interaction of Platinum Complex/Peptide Chimera as Potential Drug Candidates (Eur. J. Org. Chem. 32/2010)

Mariana S. Damian, Hanna K. Hedman, Sofi K. C. Elmroth, Ulf Diederichsen

European Journal of Organic Chemistry > 2010 > 32 > n/a - n/a

The cover picture shows the covalent DNA binding of cisplatin‐like complexes. These molecules were designed as hybrids between the platinum coordination site and positively charged peptides, which involves the covalent binding of one or two nucleobases by cisplatin‐analogous platinum complexes and the bending of double‐stranded DNA initiated by the peptide chain. An optimization of cisplatin‐like...

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DATA MINING (3)
FEATURE EXTRACTION (3)
ROAD EXTRACTION (3)
ROADS (3)
SYNTHETIC APERTURE RADAR (3)
BAYESIAN PROBABILITY THEORY (2)
CISPLATIN (2)
GENOTYPING (2)
GEOPHYSICAL TECHNIQUES (2)
HOSPITAL (2)
NETWORK TOPOLOGY (2)
POWER TRANSMISSION (2)
REMOTE SENSING BY RADAR (2)
SENSOR GEOMETRY (2)
SWITCHES (2)
TOPOLOGY (2)
URBAN AREAS (2)
3′ UNTRANSLATED REGION (1)
ADAPTIVE OPTICS (1)
ADIPOSE (1)
AGING (1)
ANTITUMOR AGENTS (1)
AORTIC AUGMENTATION INDEX (1)
ARTERY (1)
ATHLETES (1)
AUTOMATIC ROAD EXTRACTION PROCEDURE DEVELOPED (1)
B19V (1)
BAYES METHODS (1)
BLOOD PRESSURE (1)
BRAIN (1)
CARDIOVASCULAR DISEASE (1)
CLASS-AIDED FEATURE-LEVEL FUSION (1)
CLINICAL TRIAL (1)
CONTEXT (1)
CONTROLLABILITY (1)
COOPTIMIZATION FORMULATION (1)
DIASTOLIC FUNCTION (1)
DISPATCHING (1)
DNA DAMAGE (1)
DNA METHYLATION (1)
DNA STRUCTURES (1)
ECHOCARDIOGRAPHY (1)
ENDURANCE EXERCISE (1)
EPIGENETICS (1)
EPSTEIN--BARR VIRUS (1)
EPSTEIN–BARR VIRUS (1)
FLOW GATE PRICES (1)
FUSION (1)
GATED SPECT (1)
GENE EXPRESSION (1)
GENERATION DISPATCH (1)
GENERATION REVENUES (1)
GENERATION UNIT COMMITMENT OPTIMIZATION (1)
GEOMETRY (1)
GEOPHYSICAL IMAGE PROCESSING (1)
GLP‐1 (1)
HUMAN BOCAVIRUS (1)
HUMAN BOCAVIRUS 1 (1)
IEEE 118 BUS TEST CASE (1)
IMAGE FUSION (1)
IMAGE RESOLUTION (1)
IMMUNOSUPPRESSION (1)
IMMUNOSUPPRESSION, PCR (1)
INTEGER PROGRAMMING (1)
ITERATIVE FUSION (1)
ITERATIVE METHODS (1)
LAYOUT (1)
LEFT VENTRICULAR FUNCTION (1)
LINE EXTRACTION (1)
LIRAGLUTIDE (1)
LOAD PAYMENT (1)
MAPPING FILTER (1)
MARKOV RANDOM FIELD (1)
MARKOV RANDOM FIELD (MRF) (1)
MAXIMAL OXYGEN UPTAKE (1)
MICROARRAYS (1)
MIXED INTEGER PROGRAMMING (1)
MYOCARDIAL PERFUSION: SPECT (1)
NETWORK OPTIMIZATION (1)
NODAL PRICES (1)
OPTICAL SCATTERING (1)
OPTIMAL TOPOLOGY (1)
OPTIMAL TRANSMISSION SWITCHING (1)
OPTIMIZATION (1)
OXIDATIVE STRESS (1)
PAEDIATRIC (1)
PARV4 (1)
PARVOVIRIDAE (1)
PARVOVIRUS (1)
PCR (1)
PEPTIDES (1)
PHYSICAL ACTIVITY (1)
PLATINUM (1)
POINT-OF-CARE TEST (1)
POWER GENERATION DISPATCH (1)
POWER GENERATION ECONOMICS (1)
POWER GENERATION RELIABILITY (1)
POWER GENERATION SCHEDULING (1)
POWER TRANSMISSION ECONOMICS (1)
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European Journal of Clinical Microbiology & Infectious Diseases (2)
European Journal of Organic Chemistry (2)
Journal of Virological Methods (2)
The American Journal of Human Genetics (2)
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Archives of Virology (1)
BMC Medical Genomics (1)
Genome Biology (1)
IEEE Transactions on Geoscience and Remote Sensing (1)
JBIC Journal of Biological Inorganic Chemistry (1)
Journal of Nuclear Cardiology (1)
Journal of the American Chemical Society (1)
New Microbes and New Infections (1)
Pediatric Obesity (1)
Scandinavian Journal of Immunology (1)
Scandinavian Journal of Medicine & Science in Sports (1)
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INFONA - science communication portal

Search results for: K. Hedman

Liraglutide effects in a paediatric (7‐11 y) population with obesity: A randomized, double‐blind, placebo‐controlled, short‐term trial to assess safety, tolerability, pharmacokinetics, and pharmacodynamics

Vascular characteristics in young women—Effect of extensive endurance training or a sedentary lifestyle

Respiratory motion reduction with a dual gating approach in myocardial perfusion SPECT: Effect on left ventricular functional parameters

DNA methylation patterns associated with oxidative stress in an ageing population

Replication of and Protein Synthesis by TT Viruses

Detection and monitoring of human bocavirus 1 infection by a new rapid antigen test

The chemokine CXCL-10 and viral DNA levels correlate with different stages of Parvovirus B19 infection

Torque teno virus primary infection in children

Microsphere-based IgG avidity assays using as model human parvovirus B19 and CMV

Bones hold the key to virus history and epidemiology

Multiplex detection of all currently known human polyomaviruses

A new quantitative PCR for human parvovirus B19 genotypes

Female athlete's heart: Systolic and diastolic function related to circulatory dimensions

A two-step real-time PCR assay for quantitation and genotyping of human parvovirus 4

Global Analysis of DNA Methylation Variation in Adipose Tissue from Twins Reveals Links to Disease-Associated Variants in Distal Regulatory Elements

Global Analysis of DNA Methylation Variation in Adipose Tissue from Twins Reveals Links to Disease-Associated Variants in Distal Regulatory Elements

Gene expression changes with age in skin, adipose tissue, blood and brain

Platinum Interference with siRNA Non-seed Regions Fine-Tunes Silencing Capacity

Comparison of Th‐cell Immunity Against Human Bocavirus and Parvovirus B19: Proliferation and Cytokine Responses are Similar in Magnitude but More Closely Interrelated with Human Bocavirus

Synthesis and DNA Interaction of Platinum Complex/Peptide Chimera as Potential Drug Candidates (Eur. J. Org. Chem. 32/2010)

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