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A novel signal amplification strategy based on a Pb2+-dependent DNAzyme is proposed for detecting Pb2+ and radon through Pb2+-induced DNAzyme cleavage and the auto-assembly of a duplex-hemin/G-quadruplex with two loop-stem structures and enzyme-mimicking catalytic activity. First, the Pb2+-specific DNAzyme cleaves a primer sequence, which induces assembly of the hairpin probe Hp1/Hp2 into a double...
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