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The development of efficient gene delivery systems targeting the lung endothelium remains a serious challenge. This study reports on the design and optimization of a multifunctional envelope‐type nanodevice (MEND) for an efficient siRNA delivery to the lung endothelium based on GALA‐peptide targeting ability. The incorporation of a pH‐sensitive lipid (YSK05) results in a dramatic improvement in silencing...
Engineering nanocarrier systems for efficient small interfering RNA (siRNA) delivery requires advanced materials that can achieve specific cellular targeting together with efficient intracellular trafficking for reaching target sites in the cytosol. In article number 1807677, Ikramy A. Khalil, Hideyoshi Harashima, and co‐workers use nanoparticles modified with the GALA peptide as targeted therapy...
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