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Background
Ubiquitin‐mediated degradation of the Mas‐related G protein‐coupled receptor C (MrgC) reduces the number of receptors. However, the specific deubiquitinating enzyme antagonize this process has not been reported. In this study, we investigated the effect of ubiquitin‐specific protease‐48 (USP48) on bone cancer pain (BCP) and its effect on MrgC.
Methods
A mouse model of BCP was established...
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