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Pyruvate kinase M2 (PKM2) is a rate-limiting enzyme of aerobic glycolysis in cancer cells and plays important roles in cancer metabolism and growth. Here we show that vitamin K 3 and K 5 (VK 3 and VK 5 ) are relatively specific PKM2 inhibitors. VK 3 and VK 5 showed a significantly stronger potency to inhibit PKM2 than to inhibit PKM1 and PKL, 2 other...
The failure of adenovirus-mediated gene therapy often derives from the absence of coxsackie and adenovirus receptor (CAR) expression in target cells. We hypothesize that the slight up-regulation of CAR expression might boost the effect of adenovirus-mediated gene therapy in ovarian cancer. To test this hypothesis, we transfected full-length and intracellular-domain-deleted (tailless) CAR plasmids...
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