Search results for: Xingyu Jiang

Items from 1 to 20 out of 205 results

article

Perovskite‐Oxide‐Based Ferroelectric Synapses Integrated on Silicon

Ningchong Zheng, Yipeng Zang, Jiayi Li, Cong Shen, more

Advanced Functional Materials > 34 > 32 > n/a - n/a

Perovskite‐oxide‐based ferroelectric tunnel junctions (FTJs) hold great potential for applications in non‐volatile memory and neuromorphic computing due to their unique properties. However, the challenges in synthesizing high crystalline quality perovskite oxides directly on silicon wafer limit the applications of these FTJs in conventional Si‐based integrated circuits, let alone the neural networks...

article

Intrahippocampal Supramolecular Assemblies Directed Bioorthogonal Liberation of Neurotransmitters to Suppress Seizures in Freely Moving Mice

Chengling Wu, Jingyu Xie, Qingxin Yao, Yilin Song, more

Advanced Materials > 36 > 27 > n/a - n/a

The precise delivery of anti‐seizure medications (ASM) to epileptic loci remains the major challenge to treat epilepsy without causing adverse drug reactions. The unprovoked nature of epileptic seizures raises the additional need to release ASMs in a spatiotemporal controlled manner. Targeting the oxidative stress in epileptic lesions, here the reactive oxygen species (ROS) induced in situ supramolecular...

article

PROTAC Prodrug‐Integrated Nanosensitizer for Potentiating Radiation Therapy of Cancer

Shunan Zhang, Yi Lai, Jiaxing Pan, Madiha Saeed, more

Advanced Materials > 36 > 23 > n/a - n/a

Radiation therapy (RT) is one of the primary options for clinical cancer therapy, in particular advanced head and neck squamous cell carcinoma (HNSCC). Herein, the crucial role of bromodomain‐containing protein 4 (BRD4)‐RAD51 associated protein 1 (RAD51AP1) axis in sensitizing RT of HNSCC is revealed. A versatile nanosensitizer (RPB7H) is thus innovatively engineered by integrating a PROteolysis TArgeting...

article

The signalling pathways, calcineurin B‐like protein 5 (CBL5)‐CBL‐interacting protein kinase 8 (CIPK8)/CIPK24‐salt overly sensitive 1 (SOS1), transduce salt signals in seed germination in Arabidopsis

Qing Xie, Xiaochang Yin, Yu Wang, Yuting Qi, more

Plant, Cell & Environment > 47 > 5 > 1486 - 1502

For plant growth under salt stress, sensing and transducing salt signals are central to cellular Na⁺ homoeostasis. The calcineurin B‐like protein (CBL)‐CBL‐interacting protein kinase (CIPK) complexes play critical roles in transducing salt signals in plants. Here, we show that CBL5, an ortholog of CBL4 and CBL10 in Arabidopsis, interacts with and recruits CIPK8/CIPK24 to the plasma membrane. Yeast...

article

Ash1L ameliorates psoriasis via limiting neuronal activity‐dependent release of miR‐let‐7b

Wan‐Jie Du, Huan Yang, Fang Tong, Shuai Liu, more

British Journal of Pharmacology > 181 > 7 > 1107 - 1127

Background and Purpose Psoriasis is a common autoimmune skin disease that significantly diminishes patients' quality of life. Interactions between primary afferents of the somatosensory system and the cutaneous immune system mediate the pathogenesis of psoriasis. This study aims to elucidate the molecular mechanisms of how primary sensory neurons regulate psoriasis formation. Experimental Approach...

article

Healthcare Monitoring Sensors Based on Organic Transistors: Surface/Interface Strategy and Performance

Xingyu Jiang, Cheng Shi, Zi Wang, Lizhen Huang, more

Advanced Materials > 36 > 5 > n/a - n/a

Organic transistors possess inherent advantages such as flexibility, biocompatibility, customizable chemical structures, solution‐processability, and amplifying capabilities, making them highly promising for portable healthcare sensor applications. Through convenient and diverse modifications at the material and device surfaces or interfaces, organic transistors allow for a wide range of sensor applications...

article

The role of microRNA in psoriasis: A review

Xingyu Jiang, Rongcan Shi, Rui Ma, Xinyi Tang, more

Experimental Dermatology > 32 > 10 > 1598 - 1612

Psoriasis is a chronic immune‐mediated inflammatory skin disease that involves a complex interplay between infiltrated immune cells and keratinocytes. Great progress has been made in the research on the molecular mechanism of coding and non‐coding genes, which has helped in clinical treatment. However, our understanding of this complex disease is far from clear. MicroRNAs (miRNAs) are small non‐coding...

article

Tuning Ligands Ratio Allows for Controlling Gold Nanocluster Conformation and Activating a Nonantimicrobial Thiol Fragrance for Effective Treatment of MRSA‐Induced Keratitis

Zeyang Pang, Ning Ren, Yujie Wu, Jie Qi, more

Advanced Materials > 35 > 40 > n/a - n/a

Bacterial keratitis is a serious ocular disease that affects millions of people worldwide each year, among which ≈25% are caused by Staphylococcus aureus. With the spread of bacterial resistance, refractory keratitis caused by methicillin‐resistant S. aureus (MRSA) affects ≈120 000–190 000 people annually and is a significant cause of infectious blindness. Atomically precise gold nanoclusters (GNCs)...

article

Organic Electrochemical Transistor Based on Hydrophobic Polymer Tuned by Ionic Gels

Rongxiang He, Aifeng Lv, Xingyu Jiang, Chang Cai, more

Angewandte Chemie International Edition > 62 > 37 > n/a - n/a

Hydrophobic conjugated polymers have poor ionic transport property, so hydrophilic side chains are often grafted for their application as organic electrochemical transistors (OECTs). However, this modification lowers their charge transport ability. Here, an ionic gel interfacial layer is applied to improve the ionic transport while retaining the charge transport ability of the polymers. By using the...

article

Organic Electrochemical Transistor Based on Hydrophobic Polymer Tuned by Ionic Gels

Rongxiang He, Aifeng Lv, Xingyu Jiang, Chang Cai, more

Angewandte Chemie > 135 > 37 > n/a - n/a

article

Acoustic Trapping: An Emerging Tool for Microfabrication Technology (Small 26/2023)

Chengying Yin, Xingyu Jiang, Stephen Mann, Liangfei Tian, more

Small > 19 > 26 > n/a - n/a

Microfabrication Technology Ultrasound‐based technology has the potential to significantly enhance micro‐patterning technologies, enabling new research opportunities in various fields such as tissue engineering, chemical/biochemical sensing, and materials science. More details can be found in article number 2207917 by Liangfei Tian, Bruce W. Drinkwater, and co‐workers.

article

Acoustic Trapping: An Emerging Tool for Microfabrication Technology

Chengying Yin, Xingyu Jiang, Stephen Mann, Liangfei Tian, more

Small > 19 > 26 > n/a - n/a

The high throughput deposition of microscale objects with precise spatial arrangement represents a key step in microfabrication technology. This can be done by creating physical boundaries to guide the deposition process or using printing technologies; in both approaches, these microscale objects cannot be further modified after they are formed. The utilization of dynamic acoustic fields offers a...

article

Multi‐Targeted Peptide‐Modified Gold Nanoclusters for Treating Solid Tumors in the Liver

Feng Xiao, Yao Chen, Jie Qi, Qiaofeng Yao, more

Advanced Materials > 35 > 20 > n/a - n/a

Apoptosis and autophagy determine the fate of cancer cells. However, simply promoting apoptosis of tumor cells is limited in the treatment of unresectable solid liver tumors. Generally, autophagy is considered the anti‐apoptotic “guardian”. But the pro‐apoptotic effects of autophagy can be activated by excessive endoplasmic reticulum (ER) stress. Here, amphiphilic peptide‐modified glutathione (GSH)‐gold...

article

Microfluidics‐enabled Serial Assembly of Lipid‐siRNA‐sorafenib Nanoparticles for Synergetic Hepatocellular Carcinoma Therapy

Yao Chen, Dong Zhao, Feng Xiao, Xuanyu Li, more

Advanced Materials > 35 > 13 > n/a - n/a

Multi‐component nanoparticles (mNPs) hold great potential for disease prevention and treatment. However, a major barrier is the lack of versatile platforms to accommodate steps of assembly processes of mNPs. Here the microfluidics‐enabled serial assembly (MESA) of mNPs is presented. The microfluidic chip, as a mini‐conveyor of initial materials, sequentially enables the assembly of sorafenib supramolecule,...

article

In Situ Reprogramming of Tumor‐Associated Macrophages with Internally and Externally Engineered Exosomes

Lingmin Zhang, Yinshan Lin, Songpei Li, Xiaoling Guan, more

Angewandte Chemie > 135 > 11 > n/a - n/a

The reprogramming of tumor‐associated macrophages (TAMs) has emerged as an efficient strategy for immunotherapy. However, most of the approaches did not allow the in situ reprogramming of TAM because their low efficiency, non‐specificity, or potential side effects. Herein, we produced exosomes with the clustered regularly interspaced short palindromic repeats interference (CRISPRi) internally engineered...

article

In Situ Reprogramming of Tumor‐Associated Macrophages with Internally and Externally Engineered Exosomes

Lingmin Zhang, Yinshan Lin, Songpei Li, Xiaoling Guan, more

Angewandte Chemie International Edition > 62 > 11 > n/a - n/a

article

A Bifunctional Aggregation‐Induced Emission Luminogen for Monitoring and Killing of Multidrug‐Resistant Bacteria

Ying Li, Zheng Zhao, Jiangjiang Zhang, Ryan T. K. Kwok, more

Advanced Functional Materials > 33 > 7 > n/a - n/a

article

Wet‐Adhesive Elastomer for Liquid Metal‐Based Conformal Epidermal Electronics

Jinhao Cheng, Jin Shang, Shuaijian Yang, Jiabin Dou, more

Advanced Functional Materials > 32 > 25 > n/a - n/a

Wearable electronics are increasingly used in health monitoring and treatment in different conditions. However, few devices can adhere conformally to the skin after sports and showers (sweating, deformation, friction). Here, a facile method is presented by providing a metal‐polymer conductor (MPC) made with polyethylene glycol (PEG) blended polydimethylsiloxane (PDMS) based adhesive (PPA) that encapsulates...

article

Growth Behavior of Rubrene Thin Films on Hexagonal Boron Nitride in the Early Stage

Yujia Wei, Di Xue, Lianlian Ji, Jie Lu, more

Chinese Journal of Chemistry > 40 > 11 > 1298 - 1304

Two‐dimensional materials, with an in‐plane ordered and dangling‐bonding‐free surface, are ideal substrates for fabricating high‐ quality crystalline thin films. Here, we show a systematic study on the growth of a benchmark organic semiconductor, rubrene, on hexagonal boron nitride (h‐BN) substrate via physical vapor deposition from the initial amorphous phase to the final crystalline phase; the role...

article

The shift from macrophytic to algal particulate organic matter favours dissimilatory nitrate reduction to ammonium over denitrification in a eutrophic lake

Xingyu Jiang, Guang Gao, Yang Hu, Keqiang Shao, more

Freshwater Biology > 67 > 3 > 564 - 576

In eutrophic lakes, the shift from a macrophyte‐dominated state to an algae‐dominated state changes the particulate organic matter (POM) sources, which in turn alters organic matter quality that is released and that sinks to the benthos. However, the influences of this shift on denitrification and dissimilatory nitrate reduction to ammonium (DNRA) are unclear in eutrophic lakes. Here, we elucidated...

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Search results for: Xingyu Jiang

Perovskite‐Oxide‐Based Ferroelectric Synapses Integrated on Silicon

Intrahippocampal Supramolecular Assemblies Directed Bioorthogonal Liberation of Neurotransmitters to Suppress Seizures in Freely Moving Mice

PROTAC Prodrug‐Integrated Nanosensitizer for Potentiating Radiation Therapy of Cancer

The signalling pathways, calcineurin B‐like protein 5 (CBL5)‐CBL‐interacting protein kinase 8 (CIPK8)/CIPK24‐salt overly sensitive 1 (SOS1), transduce salt signals in seed germination in Arabidopsis

Ash1L ameliorates psoriasis via limiting neuronal activity‐dependent release of miR‐let‐7b

Healthcare Monitoring Sensors Based on Organic Transistors: Surface/Interface Strategy and Performance

The role of microRNA in psoriasis: A review

Tuning Ligands Ratio Allows for Controlling Gold Nanocluster Conformation and Activating a Nonantimicrobial Thiol Fragrance for Effective Treatment of MRSA‐Induced Keratitis

Organic Electrochemical Transistor Based on Hydrophobic Polymer Tuned by Ionic Gels

Organic Electrochemical Transistor Based on Hydrophobic Polymer Tuned by Ionic Gels

Acoustic Trapping: An Emerging Tool for Microfabrication Technology (Small 26/2023)

Acoustic Trapping: An Emerging Tool for Microfabrication Technology

Multi‐Targeted Peptide‐Modified Gold Nanoclusters for Treating Solid Tumors in the Liver

Microfluidics‐enabled Serial Assembly of Lipid‐siRNA‐sorafenib Nanoparticles for Synergetic Hepatocellular Carcinoma Therapy

In Situ Reprogramming of Tumor‐Associated Macrophages with Internally and Externally Engineered Exosomes

In Situ Reprogramming of Tumor‐Associated Macrophages with Internally and Externally Engineered Exosomes

A Bifunctional Aggregation‐Induced Emission Luminogen for Monitoring and Killing of Multidrug‐Resistant Bacteria

Wet‐Adhesive Elastomer for Liquid Metal‐Based Conformal Epidermal Electronics

Growth Behavior of Rubrene Thin Films on Hexagonal Boron Nitride in the Early Stage

The shift from macrophytic to algal particulate organic matter favours dissimilatory nitrate reduction to ammonium over denitrification in a eutrophic lake

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