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The biosynthesis of 2‐phenylethanol (2‐PE) at high yields and titers is often limited by its toxicity. In this study, we describe the molecular mechanisms of 2‐PE tolerance in the multi‐stress tolerant industrial yeast, Candida glycerinogenes. They were different under 2‐PE addition or fermentation conditions. After extracellular addition of 2‐PE, C. glycerinogenes cells became rounder and bigger,...