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Etappensieg gegen Wirkstoffresistenz: Aus einer Bibliothek von über 150 1,2,4,5‐Tetraoxanen wurde ein Kandidat, RKA 182, für die präklinische Entwicklung von Malariatherapeutika selektiert. RKA 182 zeigt herausragende In‐vitro‐Aktivität gegen resistente Stämme von P. falciparum und wirkt auch gegen südostasiatische Isolate, bei denen die Artemisinin‐basierte Kombinationstherapie versagt.
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