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Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) can characterize vascular heterogeneity, and has potential utility in assessment of the efficacy of angiogenesis inhibitors in cancer treatment. Due to the heterogeneous nature of tumor microvasculature, the measured signals can be represented as the mixture of the permeability images corresponding to different perfusion rates. We recently...
Dynamic functional imaging promises powerful tools for the visualization and elucidation of important disease- causing biological processes, where the pixels often represent a composite of multiple biomarkers independent of spatial resolution. This study exploits both blind source separation and imagery marker characteristics to develop a hybrid method for the separation of mixed yet correlated biomarker...
Multi-probe dynamic biomedical imaging promises powerful tools for the visualization and elucidation of complex biological processes. Recent research aims to simultaneously dissect the spatial-temporal distributions of source signals that often represent a composite of multiple biomarkers independent of spatial resolution. We report a hybrid unmixing method for separating non-negative dependent imaging...
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