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New generation vaccines such as recombinant, antigen purified and DNA vaccines are poorly immunogenic due to the lack of an innate immune stimulus. Therefore, search of new adjuvants for these vaccines has become a topic of interesting. In new adjuvant development, saponins are outstanding candidates. Recently, increased attention has been received on plant-derived saponins in search of new adjuvant...
Saponins extracted from ginseng stems and leaves (GSLS) as well as the synergistic effect between GSLS and oil emulsion were investigated for their adjuvant effects on the immune responses of mice to vaccination against foot-and-mouth disease virus (FMDV) serotype Asia 1. In experiment A, ICR mice were subcutaneously immunized twice with FMDV antigen with or without GSLS (0, 1, 5, 10 and 20μg) at...
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