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The G-protein activations induced by κ-opioid receptor agonists, (-)U50,488H, U69,593 and TRK-820 in the mouse lower midbrain, striatum and limbic forebrain were determined by monitoring guanosine-5'-o-(3-[ 35 S]thio)triphosphate ([ 35 S]GTPγS) binding. All κ-opioid receptor agonists produced approximately 40, 20 and 10% increases of [ 35 S]GTPγS binding over...
The ability of selective μ- ([D-Ala 2 , NHPhe 4 , Gly-ol]enkephalin: DAMGO), δ 1 - ([D-Pen 2 , Pen 5 ]enkephalin: DPDPE) and δ 2 - ([D-Ala 2 ]deltorphin II: DELT II) opioid receptor agonists to activate G-proteins in the midbrain and forebrain of mice and rats was examined by monitoring the binding of guanosine-5'-O-(3-[ 35 S]thio)triphosphate...
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