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Background:Quercetin is a naturally occurring flavonoid with manybiological activities including inhibition of a number of tyrosine kinases.A phase I, dose-escalation trial of quercetin defined the maximum tolerateddose (MTD) as 1700 mg/m2 three weekly, but the vehicle, dimethylsulphoxide (DMSO) is unsuitable for further clinical development ofquercetin. Patients and methods:A water-soluble, pro-drug...
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