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The evolutionary conserved Foxo transcription factors are important regulators of quiescence and longevity. Although, Foxo1 is known to be important in regulating CD8 + T cell trafficking and homeostasis, its role in functional differentiation of antigen-stimulated CD8 + T cells is unclear. Herein, we demonstrate that inactivation of Foxo1 was essential for instructing T-bet transcription...
The cell-intrinsic mechanisms guiding naive CD8 + T cells for clonal expansion and memory generation via homeostatic proliferation (HP) are unclear. Here, we have shown that HP of naive CD8 + T cells requires IL-7-, but not IL-15-induced mTOR kinase activation. HP-induced mTOR enhances transcription factor T-bet for functional maturation and CD122 expression, which sensitizes for an...
The mechanisms underpinning integration of instructions that program naive CD8 + T cells for effector and/or memory differentiation are not well understood. Herein, we demonstrate that interleukin-12 (IL-12) enhanced and sustained antigen and costimulatory molecule (B7.1)-induced mTOR kinase activity in naive CD8 + (OT-I) T cells via phosphoinositide 3-kinase and STAT4 transcription...
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