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Background & AimsAnalysis in silico suggests that occludin (OCLN), a key receptor for HCV, is a candidate target of miR‐122; the most abundant hepatic micro RNA. We aimed to determine if miR‐122 can decrease HCV entry through binding to the 3′ UTR of OCLN mRNA.
DesignHuh7.5 cells were cotransfected with luciferase construct containing 3′ UTR of OCLN (pLuc‐OCLN) and with selected miRNAs (0–50 nM)...
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