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The relationship between airway burn and nitric oxide (NO) levels in the early burn stage was investigated by quantifying nitrite/nitrate (NOx), which are the final metabolites of NO, in 22 burn patients. Although total body surface area (TBSA) and burn index (BI) were significantly higher in patients with airway-burn than in patients without airway burn (P=0.0347 and 0.0422, respectively), no significant...
Tumor necrosis factor α (TNF-α) and tumor necrosis factor receptor I and II (TNFRI and TNFRII) were studied in 24 burn patients who had a total burn surface area (TBSA) of 50.2+/-20.4%. Immediately after the injury, both the TNFRI and TNFRII levels correlated significantly with TBSA (r=0.7344, P<0.0001; r=0.6074, P=0.0012). The TNFRI and TNFRII levels immediately after the injury were significantly...
We measured endotoxins, inflammatory cytokines and soluble adhesion molecules in the blood of 17 severe burn patients to determine the involvement of these factors in the pathophysiology of severe burns. All seventeen patients had burns with a total burn surface area of 20% or more and a burn index of 15% or more. Endotoxin was measured by an endotoxin-specific assay and tumor necrosis factor-α, interleukin...
In this study, we investigated multiple organ dysfunction syndrome (MODS) and nuclear matrix protein (NMP), which is an indicator for apoptosis, in burn patients. The subjects were 17 patients with a total burn surface area (TBSA) of 26% or more. Eight of them had MODS, and nine did not. Seven patients died, and 10 survived. The NMP value in the group with MODS (610+/-318 units/ml) was significantly...
Type II phospholipase A 2 (type II PLA 2 ), nitrite/nitrate (NO x ), tumor necrosis factor-α (TNF-α) and endotoxin were studied in burn patients. Type II PLA 2 values and NO x values were both significantly higher in the group that died, the group with shock as a complication and the group with multiple organ dysfunction syndrome (MODS) as a complication, than...
Plasma concentrations of endothelin-1 (ET-1) and thrombomodulin (TM) were determined in patients with burns to examine their relation to the severity of illness. Tumor necrosis factor-α (TNF-α) was also measured, and its relationship to ET-1 and TM determined. Twenty-three burn patients were evaluated, who had a total burn surface area (TBSA) of at least 20 per cent. ET-1 was measured by radioimmunoassay...
Blood levels of various cytokines were determined in patients with burn injury immediately after the accident, and the relationship between cytokines and morbid condition was investigated. There was almost no marked elevation of cytokines in the early stage of burn injury. Throughout the entire course, tumour necrosis factor alpha, interleukin 6 and interleukin 8, as cytokines, showed high levels...
The plasma concentrations of type II phospholipase A 2 (type II PLA 2 ) and eicosanoids, such as leukotriene B 4 (LTB 4 ), 6-keto-prostaglandin F 1α (6-keto-PGF 1α ), and thromboxane B 2 (TXB 2 ), were determined by radioimmunoassay in 23 patients with burns covering at least 20 per cent of their body surface. Cytokines such...
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