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The imaging rate of conventional atomic force microscopy (AFM) is too low to capture the dynamic behavior of biomolecules. To overcome this problem, we have been developing various devices and techniques, including small cantilevers and high-speed scanners. The feedback bandwidth in the tapping-mode now exceeds 100 kHz and hence the maximum possible imaging rate reaches 25 frames per sec (fps). Importantly...
Biological macromolecules are highly dynamic. Their functions results from dynamic structural changes and dynamic interactions with other molecules. The visualization of the dynamic processes at high spatial and temporal resolution appears to be straightforward to understanding the functional mechanisms of biological macromolecules. Such visualization is only possible by the atomic force microscope...
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