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Since a deletion/insertion polymorphism in the promoter region of the apolipoprotein C-I (APOC1) gene has been reported to be associated with late-onset Alzheimer's disease (LOAD), we examined the hypothesis in a Korean population with 120 LOAD cases and 132 age-matched controls. The frequency of APOC1 insertion allele (H2) was significantly increased in LOAD than in controls, giving an odds ratio...
Alzheimer's disease (AD) is a multifactorial disorder with possible involvement of several genetic and environmental factors. For late-onset AD (LOAD), the ε4 allele of apolipoprotein E (APOE) has been identified as a major susceptible gene. However, the observation that APOE ε4 accounted for approximately one half of the genetic variance of LOAD prompted many researchers to undertake genome surveys...
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