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Dendritic cells are the only antigen-presenting cells which can initiate a T cell-dependent immune response. This ability most probably depends on the coordinated expression of a set of specialized genes, including some as yet unknown. In order to identify such novel genes, we have generated human DC by culturing CD34 + hematopoietic progenitor cells isolated from cord blood in the presence...
Dendritic cells (DC) are professional antigen presenting cells which are required for the initiation of immune responses. As chemokines are thought to play a central role in the recruitment of lymphocytes during immune responses, we examined the chemokine repertoire expressed by DC. DC grown from human cord blood CD34 + hematopoietic progenitors cultured for 12 days in the presence of GM-CSF...
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