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Synapsin I is a synaptic vesicle-associated protein, participating in synapse formation, regulation of the synthesis of other synaptic vesicle proteins and promotion of neurotransmitter release. The aim of present study was to detect whether regional alteration of synapsin I occurred in the hippocampal formation of Alzheimers disease (AD) patients. Samples of hippocampus from ten female AD patients...
Emerging evidence has demonstrated the neuroprotection of estrogen in Alzheimers disease (AD). The hippocampus, an important target of estrogen action, is severely affected in the Alzheimer process. The aim of present study was to detect the distribution of estrogen receptor- (ER-) and the relationship between ER--containing neurons and the pretangles stained by Alz-50 in the hippocampus of AD patients...
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