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It is relevant to cell physiology that nitric oxide (NO) reacts with both cytochrome oxidase (CcOX) and oxygenated myoglobin (MbO 2 ). In this respect, it has been proposed [Pearce, L.L., et al. (2002) J. Biol. Chem. 277, 13556–13562] that (i) CcOX in turnover out-competes MbO 2 for NO, and (ii) NO bound to reduced CcOX is “metabolized” in the active site to nitrite by reacting with...
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