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Three tigliane-type diterpenoids, langduin A, 12-deoxyphorbol-13-hexadecanoate and prostratin, were isolated from the roots of Euphorbia fischeriana. The first two are new compounds. The third has been isolated for the first time from this plant and showed analgesic and sedative activities in preliminary experiments with mice. The structures have been determined on the basis of spectral methods.
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