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The present study investigated the role of mitogen-activated protein kinase (MAPK) in orofacial neuropathic pain following chronic constriction injury of the infraorbital nerve (ION-CCI). Experiments were carried out on male Sprague–Dawley rats weighing between 200 and 230 g. The ION was separated from adhering tissue, and two ligatures (5–0 chromic gut) were tied loosely around it. We examined the...
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