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We report the synthesis and biochemical evaluation of a number of 4-hydroxyphenyl ketones as potential inhibitors of the enzyme 17β-hydroxysteroid dehydrogenase (17β-HSD). In particular, we evaluated compounds against the catalysis of the conversion of androstenedione (AD) to testosterone (T) [17β-HSD type 3 (17β-HSD3)], furthermore, in an effort to determine the specificity of our compounds, we evaluated...
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