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A series of N‐acylhydrazonyl‐thienyl derivatives (compounds 2 and 3), mainly of the type 2‐(aryl‐CHNNHCOCH2)‐thiene (2: aryl = substituted‐phenyl; 3: aryl = heteroaryl) were evaluated against Mycobacterium tuberculosis. Particularly active compound was 3 (heteroaryl = 5‐nitrothien‐2‐yl or 5‐nitrofuran‐2‐yl) with MIC values of 8.5 and 9.0 μM, respectively. Moderately active compounds were compound...
A series of α‐ and β‐pyran naphthoquinones (lapachones) have been synthesized and evaluated for their in‐vitro antibacterial activity against Mycobacterium tuberculosis strain H37Rv (ATCC 27294) using the Alamar‐Blue susceptibility test; the activity was expressed as the minimum inhibitory concentration (MIC) in μg/mL. The synthetic methodology consisted of the formation of methylene and aryl o‐quinone...
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