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DNA polymerase λ is a novel enzyme of the family X of DNA polymerases. The recent demonstration of an intrinsic 5′-deoxyribose-5′-phosphate lyase activity, a template/primer dependent polymerase activity, a distributive manner of DNA synthesis and sequence similarity to DNA polymerase β suggested a novel β-like enzyme. All these properties support a role of DNA polymerase λ in base excision repair...
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