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A diverse number of chemicals present in the environment may be detrimental to the development and reproduction of wildlife and humans. These chemicals exert their effect through mimicking endogenous estrogens. Two xenoestrogens that are currently produced in large volumes are alkylphenols and bisphenol A (BPA). These chemicals demonstrate estrogenic activity; they increase the proliferation of estrogen...
Excess estrogen exposure in developing individuals increases the risk of developing breast cancer later in life. This excess estrogen can originate from high levels of maternal endogenous estrogens or from exposure to exogenous endocrine disrupting compounds that mimic estrogen actions. One of those compounds is the ubiquitous bisphenol A or BPA, a chemical that has been found in over 90% of the...
Epithelial-stromal interactions play a crucial role in normal embryonic development and carcinogenesis of the human breast while the underlying mechanisms of these events remain poorly understood. Here, we constructed a physiologically relevant, 3D culture surrogate of complex human breast tissue that included a tri-culture system made up of human mammary epithelial cells (MCF10A), fibroblasts and...
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