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ObjectivesTo investigate, using three‐dimensional power Doppler ultrasound (3D‐PDU), alterations in cervical intratumoral vascularization during and after radiotherapy.
MethodsBetween 2004 and 2009 we enrolled into the study 37 patients with FIGO Stages IB1–IIB cervical carcinoma who were undergoing radiotherapy. Serial 3D‐PDU scans were performed during treatment, providing ultrasonographic measurement of tumor size, vascularization index, flow index and vascularization flow index, as well as monthly for 3 months post‐treatment and tri‐monthly thereafter, until vascularity was undetectable on two consecutive occasions. Physical examination, cervical cytology and serum marker evaluation were performed every 3–6 months for the first 5 years following treatment. Patients evaluated after a 2‐year tumor‐free interval and those with clinically assessed positive findings at follow‐up underwent 3D‐PDU to detect possible local disease...
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