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ABCG2 is a substantial member of the ABC transporter superfamily that plays a significant role in multidrug resistance in cancer. Until recently, the 3D structure of ABCG2 has not been resolved, which resulted in the limitation of developing potential ABCG2 inhibitors using structure‐based drug discovery. Herein, eMolecules, ChEMBL, and ChEBI databases, containing >25 million compounds, were virtually...
A series of novel-substituted chalcone analogs were synthesized and evaluated for antiproliferative activity against estrogen receptor-positive MCF-7 breast cancer cell lines. Among the synthesized derivatives 4a, 5a, 5b, 5c, 5e, 5′a, and 5′d show good antiproliferative activity as compared to standard tamoxifen. The study highlighted the advantage of introducing the amine side chain pharmacophore...
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