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A series of several linear and macrocyclic tetrapeptide derivatives based on Nα-dinicotinoyl-bis[L-leucyl-L-phenylalaninyl] acid hydrazide as starting material is synthesized. Treatment of acid hydrazide with cyclic alkanones gave the corresponding tetrapeptide cycloalkanone derivatives. Condensation of hydrazide with substituted acetophenone or acetylpyridine derivatives gave the corresponding Schiff...
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