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DuP-697 (5-bromo-2-(4-fluorophenyl)-3-[4-(methylsulfonyl)phenyl]-thiophene), like celecoxib and rofecoxib, is a vicinal diaryl heterocycle highly selective cyclooxygenase-2 (COX-2) inhibitor. The aim of the study was to evaluate prenatal tolerability of DuP-697. The drug was administered orally in Tween 80 water suspension once a day to pregnant Wistar rats, on Days 7-18 of gestation. The initial...
The effect of the mixture of paracetamol and caffeine on prenatal development in rats was studied. Paracetamol:caffeine was prepared with a 5:1 ratio (w/w) between compounds and administered orally in Tween-80 water suspension once a day to pregnant Wistar rats on gestation days 8 through 14 (plug=day 1). The low dose was similar to the preparation available over-the-counter (OTC), 3.5mg/kg of paracetamol...
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