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Predicting the locations of Response Elements (RE) has received considerable attention in the field of gene sequence analysis and bioinformatics. Protein53 (p53) has a prominent role in the cell cycle and cancer prevention; it functions as a transcription factor and binds with p53 REs in the DNA. The identification of p53 response elements enlightens the unknown functions and characteristics of p53...
The cell is a highly organized system of interacting molecules including DNA, proteins, mRNAs and miRNAs. Analyzing the cell from a systems perspective by integrating different types of data helps reveal the complexity behind the biological process. Although there is emerging evidence that some microRNAs can function as oncogenes or tumour suppressors, the role of microRNAs in mediating cancer progression...
The past decades have witnessed advances in genomic technology; and this has allowed laboratories to generate vast amount of biological data, including microarray gene expression data. Effective analysis of the data helps in better understanding the mechanisms behind the complex behavior of the cell. Actually, a huge body of research focuses on the role of gene regulatory networks (GRNs) in controlling...
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