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Multiple pathogenic genetic variants are associated with pancreatitis in patients of European (EA) and Asian ancestries, but studies on patients of African ancestry (AA) are lacking. We evaluated the prevalence of known genetic variations in African-American subjects in the US.We studied prospectively enrolled controls (n = 238) and patients with chronic (CP) (n = 232) or recurrent acute pancreatitis...
Background The optimal approach to the drainage of malignant obstruction at the liver hilum remains uncertain. We aim to compare percutaneous transhepatic biliary drainage (PTBD) to endoscopic retrograde cholangiography (ERC) as the first intervention in patients with cholestasis due to suspected malignant hilar obstruction (MHO). Methods The INTERCPT trial is a multi-center, comparative effectiveness,...
Acute pancreatitis (AP) has a wide range of pathological features, radiological appearances, and treatment options (1). In most cases, it is a mild and self-limiting disease. However, severe disease develops in approximately 20% of patients associated with local and systemic complications (2–5). Fluid collections commonly complicate AP and occur in up to half of cases of patients with moderate-to-severe...
Advances in cross-sectional imaging, including magnetic resonance cholangiopancreatography (MRCP) and endoscopic ultrasound (EUS), have rendered endoscopic retrograde cholangiopancreatography (ERCP) a primarily therapeutic modality. Biliary sphincterotomy and stent placement are frequently part of the management of large bile duct stones, the relief of obstructive jaundice associated with benign and...
Endoscopic retrograde cholangiopancreatography (ERCP) is a technically-demanding procedure. The ability to selectively cannulate the bile duct and pancreatic duct (PD) quickly and atraumatically is the key to successful therapeutic ERCP, and to minimizing post-ERCP complications, especially pancreatitis (PEP). Prophylactic stenting of the PD has significantly reduced the risk of severe PEP. Difficult...
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