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Increased serum level of homocysteine is an independent risk factor for vascular disease. The effect of dl-homocysteine on the endothelial production of kynurenic acid, an antagonist of α7-nicotinic and N-methyl-d-aspartate (NMDA) glutamate receptors, has been evaluated in vitro and in vivo. In rat aortic rings, dl-homocysteine at 40–100 μM enhanced, whereas at ≥400 μM decreased the synthesis of kynurenic...
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