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Purpose In this pharmacokinetic/pharmacodynamic meta-analysis, we investigated relationships between clinical endpoints and sunitinib exposure in patients with advanced solid tumors, including patients with gastrointestinal stromal tumor (GIST) and metastatic renal cell carcinoma (mRCC). Methods Pharmacodynamic data were available for 639 patients of whom 443 had pharmacokinetic data. Sunitinib...
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