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Traditionally, organic chemical reactions require organic solvents, toxic catalysts, heat, or high pressure. However, copper‐free click chemistry has been shown to have favorable reaction rates and orthogonality in water, buffer solutions, and physiological conditions without toxic catalysts. Strain‐promoted azide‐alkyne cycloaddition and inverse electron‐demand Diels–Alder reactions are representative...
Nanomedicine is extensively employed for cancer treatment owing to its unique advantages over conventional drugs and imaging agents. This increased attention to nanomedicine, however, has not fully translated into clinical utilization and patient benefits due to issues associated with reticuloendothelial system clearance, tumor heterogeneity, and complexity of the tumor microenvironment. To address...
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